1900

• Buffalo Bill Cody's Wild West and Congress of Rough Riders came into town

• Small pox, typhoid fever and diphtheria ran rampant in the early 1900's

1901

• First medical patient in Scioto County is accepted

1902

• Mitchellace opens as world's largest shoestring plant

• Millbrook Park opens in New Boston

• Park Hospital opened by S.S. Halderman and J.J. Rardin on Ninth St near Tracy Park

• Portsmouth Library was built with funding from Andrew Carnegie

• Ordinance was adopted to establish salaries for city officials

1904

• Toy Pistol Factory exploded killing one person

1905

• Carlyle Paving Brick Company was built in Sciotoville

1906

• Selby Shoe Co. created

1907

• Highland School bids accepted by the City Board of Education

• Portsmouth streetcar workers strike

• Captain T.A. McMahon of the Salvation Army raided saloons spreading the word of the evils of liquor  He was later dismissed from the Salvation Army.

1909

• Levy passed to purchase and construct Portsmouth High School

• Portsmouth Shoemakers played New York Giants